Article
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.
PloS one - 1 Jan 2012
Yan Lifeng, Zhao Lin, Long Yan, Zou Peng, Ji Guixiang, Gu Aihua, Zhao Peng
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA methylation, DNA synthesis, and DNA repair. In addition, it is a possible risk factor in neural tube defects (NTDs). The association of the C677T polymorphism in the MTHFR gene and NTD susceptibility has been widely demonstrated, but the results remain inconclusive. In this study, we performed...
Topics
- Case-Control Studies
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Models, Genetic
- Neural Tube Defects