Article
Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis.
Fetal and pediatric pathology - 1 Apr 2022
Tabatabaei Razieh Sadat, Fatahi-Meibodi Neda, Meibodi Bahare, Javaheri Atiyeh, Abbasi Hajar, Hadadan Amaneh, Bahrami Reza, Mirjalili Seyed Reza, Karimi-Zarchi Mojgan, Neamatzadeh Hossein
Abstract excerpt
Background MTHFR gene may be a key epigenetic regulation-related factor crucial during embryogenesis. We performed a meta-analysis to determine the association of fetal MTHFR C677T polymorphism with neural tube defects (NTDs).Methods A comprehensive literature search of the PubMed, Embase, and CNKI database was performed up to April 10, 2020.Results A total of 19 case-control studies with 2,228 NTDs cases and...
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