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Article

Association between MTHFD1 G1958A polymorphism and neural tube defects susceptibility: a meta-analysis.

PloS one - 1 Jan 2014

Jiang Jianxin, Zhang Yanfei, Wei Liang, Sun Zhiyang, Liu Zhongmin

Abstract excerpt

OBJECTIVES: The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, as one of the key genes involved in the folate pathway, has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs). However, the results of published studies are contradictory and inconclusive. Thus, this meta-analysis aimed to evaluate the effect of the common polymorphism in the MTHFD1 gene, the G1958A...

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Source

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Identifiers

PMID: 24977710
DOI: 10.1371/journal.pone.0101169
PMCID: PMC4076264

Genes

MTHFD1

Variants

rs2236225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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