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Article

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.

PloS one - 1 Jan 2013

Zhang Ti, Lou Jiao, Zhong Rong, Wu Jing, Zou Li, Sun Yu, Lu Xuzai, Liu Li, Miao Xiaoping, Xiong Guanglian

Abstract excerpt

BACKGROUND: Neural Tube Defects (NTDs) are among the most prevalent and most severe congenital malformations worldwide. Polymorphisms in key genes involving the folate pathway have been reported to be associated with the risk of NTDs. However, the results from these published studies are conflicting. We surveyed the literature (1996-2011) and performed a comprehensive meta-analysis to provide empirical evidence...

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Source

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Identifiers

PMID: 23593147
DOI: 10.1371/journal.pone.0059570
PMCID: PMC3617174

Genes

MTHFR
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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