Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.

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Article

Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.

The Turkish journal of pediatrics - 1 Jan 2000

Boduroğlu Koray, Alanay Yasemin, Alikaşifoğlu Mehmet, Aktaş Dilek, Tunçbilek Ergül

Abstract excerpt

Maternal folic acid intake in the periconceptional period is strongly related to reduction in recurrence and occurrence of birth defects involving the neural tube. Among the single nucleotide polymorphisms (SNPs) influencing the folate metabolism, the methylenetetrahydrofolate reductase (MTHFR) gene has been the one most exclusively studied. Many studies have reported significant association between MTHFR 677C>T...

Topics

Adult
Child
Female
Genotype
Humans
Male
Neural Tube Defects
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Risk Factors
Seroepidemiologic Studies
Turkey

Source

Open in PubMed

Identifiers

PMID: 16363341

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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