Variants in MTHFR gene and neural tube defects susceptibility in China.

doi:10.1007/s11011-015-9662-4

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Article

Variants in MTHFR gene and neural tube defects susceptibility in China.

Metabolic brain disease - 1 Aug 2015

Wang Yongxin, Liu Yuan, Ji Wenyu, Qin Hu, Wu Hao, Xu Danshu, Turtuohut Tukebai, Wang Zengliang

Abstract excerpt

Neural tube defect (NTD) is a severe congenital birth abnormalities involving incomplete neural tube closure. 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene plays key role in folate cycle and methylation cycle, which could affect the DNA synthesis, repair and methylation. In this study, we aim to investigate the correlation between MTHFR polymorphisms and NTD-affected pregnancy. There were 444...

Topics

Adult
Case-Control Studies
China
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Neural Tube Defects
Polymorphism, Single Nucleotide
Pregnancy
Risk Factors
Young Adult

Source

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Identifiers

PMID: 25855017
DOI: 10.1007/s11011-015-9662-4

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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