Article
Association between MTHFR C677T polymorphism and neural tube defect risks: A comprehensive evaluation in three groups of NTD patients, mothers, and fathers.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2015
Yang Yi, Chen Jie, Wang Beiyu, Ding Chen, Liu Hao
Abstract excerpt
BACKGROUND: The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) gene has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs). The association of the C677T polymorphism in the MTHFR gene and NTD susceptibility has been widely demonstrated, but the results are inconclusive. In this study, we performed a meta-analysis in three groups to investigate the...
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