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Article

"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".

Metabolic brain disease - 1 Feb 2015

Yadav Upendra, Kumar Pradeep, Yadav Sushil Kumar, Mishra Om Prakash, Rai Vandana

Abstract excerpt

Epidemiological studies have evaluated the association between maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD risk are conflicting. To derive a clearer picture of association...

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Source

Identifiers

PMID: 25005003
DOI: 10.1007/s11011-014-9575-7

Genes

MTHFR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".PMID 25005003Read ↗

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.Semantic proximity Read ↗

Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.Semantic proximity Read ↗

Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association.Semantic proximity Read ↗

MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-analysis.Semantic proximity Read ↗

Variants in MTHFR gene and neural tube defects susceptibility in China.Semantic proximity Read ↗

Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: a meta-analysis.Semantic proximity Read ↗

Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.Semantic proximity Read ↗

[Meta-analysis on relationship between the Chinese maternal MTHFR gene polymorphism(C677T) and neural tube defects in offspring].Semantic proximity Read ↗

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.Semantic proximity Read ↗

Association between MTHFR C677T polymorphism and neural tube defect risks: A comprehensive evaluation in three groups of NTD patients, mothers, and fathers.Semantic proximity Read ↗

Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis.Semantic proximity Read ↗

Association between the methionine synthase A2756G polymorphism and neural tube defect risk: a meta-analysis.Semantic proximity Read ↗

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