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Article

Mitochondrial SKN-1/Nrf mediates a conserved starvation response.

Cell metabolism - 3 Oct 2012

Paek Jennifer, Lo Jacqueline Y, Narasimhan Sri Devi, Nguyen Tammy N, Glover-Cutter Kira, Robida-Stubbs Stacey, Suzuki Takafumi, Yamamoto Masayuki, Blackwell T Keith, Curran Sean P

Abstract excerpt

SKN-1/Nrf plays multiple essential roles in development and cellular homeostasis. We demonstrate that SKN-1 executes a specific and appropriate transcriptional response to changes in available nutrients, leading to metabolic adaptation. We isolated gain-of-function (gf) alleles of skn-1, affecting a domain of SKN-1 that binds the transcription factor MXL-3 and the mitochondrial outer membrane protein PGAM-5....

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Identifiers

PMID: 23040073
DOI: 10.1016/j.cmet.2012.09.007
PMCID: PMC3774140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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