Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.

Life science alliance - 1 Dec 2021

Soo Sonja K, Traa Annika, Rudich Paige D, Mistry Meeta, Van Raamsdonk Jeremy M

Abstract excerpt

The mitochondrial unfolded protein response (mitoUPR) is an evolutionarily conserved pathway that responds to mitochondria insults through transcriptional changes, mediated by the transcription factor ATFS-1/ATF-5, which acts to restore mitochondrial homeostasis. In this work, we characterized the role of ATFS-1 in responding to organismal stress. We found that activation of ATFS-1 is sufficient to cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosol

Share to Endoplasmic Reticulum

Share to Forkhead Transcription Factors

Share to Immunity, Innate

Share to Longevity

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 34583931
DOI: 10.26508/lsa.202101182
PMCID: PMC8500221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.PMID 34583931Read ↗

The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevitySemantic proximity Read ↗

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.Semantic proximity Read ↗

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunitySemantic proximity Read ↗

Cardioprotection by the mitochondrial unfolded protein response requires ATF5Semantic proximity Read ↗

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.Semantic proximity Read ↗

Hijacking Cellular Stress Responses to Promote LifespanSemantic proximity Read ↗

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.Semantic proximity Read ↗

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and diseaseSemantic proximity Read ↗

Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular SenescenceSemantic proximity Read ↗

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.Semantic proximity Read ↗

Molecular mechanism of ATF6 in unfolded protein response and its role in diseaseSemantic proximity Read ↗

The mitochondrial unfolded protein response and its diverse roles in cellular stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.