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Article

Activated SKN-1 alters the aging trajectories of long-lived Caenorhabditis elegans mutants.

Genetics - 17 Apr 2025

Turner Chris D, Curran Sean P

Abstract excerpt

In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, chronic activation of SKN-1 results in diminished health and a reduction of lifespan. Here, we demonstrate the necessity of modulating SKN-1 activity to maintain the longevity-promoting effects associated with genetic mutations that...

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Identifiers

PMID: 39874273
DOI: 10.1093/genetics/iyaf016
PMCID: PMC12005260

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