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Article

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans.

PLoS biology - 1 Jul 2024

Yanagi Katherine S, Jochim Briar, Kunjo Sheikh Omar, Breen Peter, Ruvkun Gary, Lehrbach Nicolas

Abstract excerpt

The conserved SKN-1A/Nrf1 transcription factor regulates the expression of proteasome subunit genes and is essential for maintenance of adequate proteasome function in animal development, aging, and stress responses. Unusual among transcription factors, SKN-1A/Nrf1 is a glycoprotein synthesized in the endoplasmic reticulum (ER). N-glycosylated SKN-1A/Nrf1 exits the ER and is deglycosylated in the cytosol by the...

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Identifiers

PMID: 38991033
DOI: 10.1371/journal.pbio.3002720
PMCID: PMC11265709

Genes

NGLY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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