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Krüppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity

2025-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Maintenance of lipid and redox homeostasis are essential for stress resistance and longevity, but the transcriptional networks coordinating these processes remain incompletely understood. In Caenorhabditis elegans , the transcription factors SKN-1A/Nrf1 and SKN-1C/Nrf2 mediate distinct stress responses that promote proteostasis, lipid homeostasis, and oxidative stress. Here we identify the Krüp...

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Literature Corpus work
5d7385c6-bc55-5f31-a3dd-b21d57b0ee89
DOI
10.1101/2025.11.22.689963
Open publication

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Krüppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevityDOI 10.1101/2025.11.22.689963
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