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The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

23 Nov 2010

Abstract excerpt

PURPOSE OF REVIEW: The vertebrate cap'n'collar family transcription factor Nrf2 and its invertebrate homologues SKN-1 (in worms) and CncC (in flies) function as master mediators of antioxidant and detoxification responses and regulators of the cellular redox state. Nrf2 controls gene expression programs that defend various tissues against diverse electrophilic stressors and oxidative insults, thus protecting the...

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PMID: 21102319
DOI: 10.1097/mco.0b013e32834136f2

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