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SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation

25 Mar 2023

Abstract excerpt

The functionally differentiated mammary gland adapts to extreme levels of stress from increased demand for energy by activating specific protective mechanisms to support neonatal health. Here, we identify the breast tumor suppressor gene, single-minded 2 s (SIM2s) as a novel regulator of mitophagy, a key component of this stress response. Using tissue-specific mouse models, we found that loss of Sim2 reduced...

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PMID: 36966227
DOI: 10.1038/s41418-023-01146-9

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