Article

Metabolic regulation of misfolded protein import into mitochondria

2023-03-29

Abstract excerpt

Mitochondria are the cellular energy hub and central target of metabolic regulation. Mitochondria also facilitate proteostasis through pathways such as the ‘mitochondria as guardian in cytosol’ (MAGIC) whereby cytosolic misfolded proteins (MPs) are imported into and degraded inside mitochondria. In this study, a genome-wide screen in yeast uncovered that Snf1, the yeast AMP-activated protein kinase (AMPK), inhibit...

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Literature Corpus work: efddacbb-96e4-55ba-b723-cac40510b99c
DOI: 10.1101/2023.03.29.534670

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