Article
Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Wang Huabo, Lu Jie, Mandel Jordan A, Zhang Weiqi, Schwalbe Marie, Gorka Joanna, Liu Ying, Marburger Brady, Wang Jinglin, Ranganathan Sarangarajan, Prochownik Edward V
Abstract excerpt
BACKGROUND & AIMS: Hepatoblastoma (HB), the most common pediatric liver cancer, often bears β-catenin mutations and deregulates the Hippo tumor suppressor pathway. Murine HBs can be generated by co-expressing β-catenin mutants and the constitutively active Hippo effector YAPS127A. Some HBs and other cancers also express mutants of NFE2L2/NRF2 (NFE2L2), a transcription factor that tempers oxidative and...
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