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Effects of <i>Nf1</i> on sleep behavior are mediated through starvation caused by deficits in SARM1 dependent NAD+ metabolism

2024-09-14

Abstract excerpt

<h4>Summary</h4> Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant disease which predisposes to the formation of tumors, and is also associated with behavioral phenotypes, including sleep disturbances. As loss of the NF1 protein has been recently associated with metabolic dysfunction, we explored the relationship between metabolic and behavioral phenotypes through metabolomic analysis of Drosop...

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Literature Corpus work
23b96296-ba57-5c28-a22f-84e098a273eb
DOI
10.1101/2024.09.14.612058
Open publication

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Effects of <i>Nf1</i> on sleep behavior are mediated through starvation caused by deficits in SARM1 dependent NAD+ metabolismDOI 10.1101/2024.09.14.612058
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