Article

Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants

2024-07-12

Abstract excerpt

In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, chronic activation of SKN-1 results in diminished health and a reduction of lifespan. Here we demonstrate the necessity of modulating SKN-1 activity to maintain the longevity-promoting effects associated with genetic mutations that imp...

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Literature Corpus work: 8945a46d-fb88-51f5-a812-90e528d9fc71
DOI: 10.1101/2024.07.09.602737

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