Article
Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus.
Clinical & developmental immunology - 1 Jan 2012
Koldobskaya Yelena, Ko Kichul, Kumar Akaash A, Agik Sandra, Arrington Jasmine, Kariuki Silvia N, Franek Beverly S, Kumabe Marissa, Utset Tammy O, Jolly Meenakshi, Skol Andrew D, Niewold Timothy B
Abstract excerpt
Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder characterized by differences in autoantibody profiles, serum cytokines, and clinical manifestations. We have previously conducted a case-case genome-wide association study (GWAS) of SLE patients to detect associations with autoantibody profile and serum interferon alpha (IFN-α). In this study, we used public gene expression data sets...
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