Identification of genetic variants in B cell expressed genes associated with systemic lupus erythematosus in African American females.

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated B cell responses and pathogenic autoantibody production. Given the central role that B cells play in SLE pathogenesis, we aimed to characterize genetic variation within the B cell compartment of African ancestry (AFR) women with SLE who are disproportionately and more severely affected by SLE. Here, we analyzed...

Topics

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• B-Lymphocytes
• Black or African American
• Gene Frequency
• Genetic Predisposition to Disease
• Genetic Variation