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Deciphering cell-specific genetic insights: Unraveling the immunogenetic landscape of systemic lupus erythematosus.

Molecular immunology - 1 Nov 2024

Zhang Huan, Zhang Zhentao, Fan Kedi, Chen Yuxi, Xu Peng, Guo Yufan, Mo Xingbo

Abstract excerpt

Functional genes within genomic loci associated with systemic lupus erythematosus (SLE), as identified by genome-wide association studies, exhibit cell-specific characteristics. This study delves into the impact of genetic variants within SLE loci on gene expression in different types of immune cells, unraveling the complex interplay between genetics and immunopathogenesis. Through the integration of genetic...

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Child
Genome-Wide Association Study
Immunogenetics
Lupus Erythematosus, Systemic
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Single-Cell Analysis

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PMID: 39476438
DOI: 10.1016/j.molimm.2024.10.005

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