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Genome-Wide Identification of Cell Type-Specific Susceptibility Genes for SLE Through the Analysis of RNA Modification-Associated SNPs.

Immunological investigations - 1 Nov 2024

Zhang Huan, Fan Kedi, Chen Yuxi, Xu Peng, Zhang Zhentao, Mo Xingbo, Guo Yufan

Abstract excerpt

INTRODUCTION: This study aimed to elucidate the functional genes associated with systemic lupus erythematosus (SLE) in various cell types through the utilization of RNAm-SNPs. METHODS: Utilizing large-scale genetic data, we identified associations between RNAm-SNPs and SLE. The association between RNAm-SNPs and bulk and single-cell mRNA expression (eQTL) and protein levels (pQTL) were examined. Mendelian...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Lupus Erythematosus, Systemic
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39230170
DOI: 10.1080/08820139.2024.2399577

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