Article
Functional relevance for associations between genetic variants and systemic lupus erythematosus.
PloS one - 1 Jan 2013
Deng Fei-Yan, Lei Shu-Feng, Zhang Yong-Hong, Zhang Zeng-Li, Guo Yu-Fan
Abstract excerpt
Systemic lupus erythematosus (SLE) is a serious prototype autoimmune disease characterized by chronic inflammation, auto-antibody production and multi-organ damage. Recent association studies have identified a long list of loci that were associated with SLE with relatively high statistical power. However, most of them only established the statistical associations of genetic markers and SLE at the DNA level...
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