Article
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.
Arthritis research & therapy - 1 Jan 2010
Kariuki Silvia N, Franek Beverly S, Kumar Akaash A, Arrington Jasmine, Mikolaitis Rachel A, Utset Tammy O, Jolly Meenakshi, Crow Mary K, Skol Andrew D, Niewold Timothy B
Abstract excerpt
INTRODUCTION: Systemic lupus erythematosus (SLE) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and clinical manifestations. SLE-associated autoantibodies and high serum interferon alpha (IFN-α) are important heritable phenotypes in SLE which are correlated with each other, and play a role in disease pathogenesis. These two heritable risk factors are...
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