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Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus

7 Apr 2022

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains incomplete. We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) with multiplexed single-cell RNA sequencing (mux-seq). Cases exhibited elevated expression of type 1 interferon–stimulated genes (ISGs) in monocytes,...

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PMID: 35389781
DOI: 10.1126/science.abf1970

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