Article
Prevalence of somatic alterations in the colorectal cancer cell genome.
Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2002
Wang Tian-Li, Rago Carlo, Silliman Natalie, Ptak Janine, Markowitz Sanford, Willson James K V, Parmigiani Giovanni, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E
Abstract excerpt
Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the vast majority of human cancers. To systematically assess nonsynonymous somatic alterations in colorectal neoplasia, we used DNA sequencing to analyze approximately 3.2 Mb of coding tumor DNA comprising 1,811 exons from...
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