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Article

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

PloS one - 1 Jan 2012

Civiero Laura, Vancraenenbroeck Renée, Belluzzi Elisa, Beilina Alexandra, Lobbestael Evy, Reyniers Lauran, Gao Fangye, Micetic Ivan, De Maeyer Marc, Bubacco Luigi, Baekelandt Veerle, Cookson Mark R, Greggio Elisa, Taymans Jean-Marc

Abstract excerpt

Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction domains, but only mutations in LRRK2 are linked to familial Parkinson's disease (PD). Independent studies suggest that LRRK2 exists in the cell as...

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Identifiers

PMID: 22952686
DOI: 10.1371/journal.pone.0043472
PMCID: PMC3430690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22952686-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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