Article
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2005
West Andrew B, Moore Darren J, Biskup Saskia, Bugayenko Artem, Smith Wanli W, Ross Christopher A, Dawson Valina L, Dawson Ted M
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's disease (PD) with a clinical appearance indistinguishable from idiopathic PD. Initial studies suggest that LRRK2 mutations are the most common yet identified determinant of PD susceptibility, transmitted in an autosomal-dominant mode of inheritance. Herein, we characterize the LRRK2 gene and transcript in human brain and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.