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Article

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

Biochimica et biophysica acta - 1 Mar 2012

Vancraenenbroeck Renée, Lobbestael Evy, Weeks Stephen D, Strelkov Sergei V, Baekelandt Veerle, Taymans Jean-Marc, De Maeyer Marc

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. Much research effort has been directed towards the catalytic core region of LRRK2 composed of GTPase (ROC, Ras of complex proteins) and kinase domains and a connecting COR (C-terminus of ROC) domain. In contrast, the precise functions of the protein-protein interaction domains, such as the leucine-rich...

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PMID: 22251894
DOI: 10.1016/j.bbapap.2011.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.PMID 22251894Read ↗

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