Article
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Biochemical and biophysical research communications - 20 Nov 2009
Greggio Elisa, Taymans Jean-Marc, Zhen Eugene Yuejun, Ryder John, Vancraenenbroeck Renée, Beilina Alexandra, Sun Peng, Deng Junpeng, Jaffe Howard, Baekelandt Veerle, Merchant Kalpana, Cookson Mark R
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited Parkinson's disease (PD). The protein is large and complex, but pathogenic mutations cluster in a region containing GTPase and kinase domains. LRRK2 can autophosphorylate in vitro within a dimer pair, although the significance of this reaction is unclear. Here, we mapped the sites of autophosphorylation within LRRK2 and found...
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