Article
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005
Smith Wanli W, Pei Zhong, Jiang Haibing, Moore Darren J, Liang Yideng, West Andrew B, Dawson Valina L, Dawson Ted M, Ross Christopher A
Abstract excerpt
Parkinson's disease (PD) is a disorder of movement, cognition, and emotion, and it is characterized pathologically by neuronal degeneration with Lewy bodies, which are cytoplasmic inclusion bodies containing deposits of aggregated proteins. Most PD cases appear to be sporadic, but genetic forms of the disease, caused by mutations in alpha-synuclein, parkin, and other genes, have helped elucidate pathogenesis....
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