Article

Structural basis for Parkinson’s Disease-linked LRRK2’s binding to microtubules

2022-01-22

Abstract excerpt

Leucine Rich Repeat Kinase 2 ( LRRK2 ) is one of the most commonly mutated genes in familial Parkinson’s Disease (PD). Under some circumstances, LRRK2 co-localizes with microtubules in cells, an association enhanced by PD mutations. We report a cryo-electron microscopy structure of the catalytic half of LRRK2, containing its kinase, which is in a closed conformation, and GTPase domains, bound to microtubules. We...

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Literature Corpus work: 35aa586f-893a-5d5a-be6f-ae237fae8fc2
DOI: 10.1101/2022.01.21.477284

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