Article
Molecular Insights and Functional Implication of LRRK2 Dimerization.
Advances in neurobiology - 1 Jan 2017
Civiero Laura, Russo Isabella, Bubacco Luigi, Greggio Elisa
Abstract excerpt
The Parkinson's disease protein leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein with an enzymatic core comprising serine-threonine kinase and GTPase activities and a number of protein-protein interaction domains. While the complex domain architecture of LRRK2 has hampered its structural investigation, there is convincing evidence that LRRK2 can form dimers in solution and in the cell and that the...
Topics
- Animals
- GTP Phosphohydrolases
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Protein Multimerization