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Article

Molecular Insights and Functional Implication of LRRK2 Dimerization.

Advances in neurobiology - 1 Jan 2017

Civiero Laura, Russo Isabella, Bubacco Luigi, Greggio Elisa

Abstract excerpt

The Parkinson's disease protein leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein with an enzymatic core comprising serine-threonine kinase and GTPase activities and a number of protein-protein interaction domains. While the complex domain architecture of LRRK2 has hampered its structural investigation, there is convincing evidence that LRRK2 can form dimers in solution and in the cell and that the...

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PMID: 28353281
DOI: 10.1007/978-3-319-49969-7_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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