Article
Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2.
Channels (Austin, Tex.) - 1 Jan 2000
Stary Anna, Kudrnac Michaela, Beyl Stanislav, Hohaus Annette, Timin Eugen N, Wolschann Peter, Guy H Robert, Hering Steffen
Abstract excerpt
A channelopathy mutation in segment IIS6 of Ca(V)1.4 (I745T) has been shown to cause severe visual impairment by shifting the activation and inactivation curves to more hyperpolarized voltages and slowing activation and inactivation kinetics. A similar gating phenotype is caused by the corresponding mutation, I781T, in Ca(V)1.2 (midpoint of activation curve (V(0.5)) shifted to -37.7 +/- 1.2 mV). We show here that...
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