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Article

Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac.

Biophysical journal - 21 Jul 2010

Paldi Tzur, Gurevitz Michael

Abstract excerpt

The voltage sensor is a four-transmembrane helix bundle (S1-S4) that couples changes in membrane potential to conformational alterations in voltage-gated ion channels leading to pore opening and ion conductance. Although the structure of the voltage sensor in activated potassium channels is available, the conformation of the voltage sensor at rest is still obscure, limiting our understanding of the...

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Identifiers

PMID: 20643063
DOI: 10.1016/j.bpj.2010.04.053
PMCID: PMC2905116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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