Article
The free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain.
PloS one - 1 Jan 2012
Schwaiger Christine S, Börjesson Sara I, Hess Berk, Wallner Björn, Elinder Fredrik, Lindahl Erik
Abstract excerpt
The gating of voltage-gated ion channels is controlled by the arginine-rich S4 helix of the voltage-sensor domain moving in response to an external potential. Recent studies have suggested that S4 moves in three to four steps to open the conducting pore, thus visiting several intermediate conformations during gating. However, the exact conformational changes are not known in detail. For instance, it has been...
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