Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

1 Aug 2012

Abstract excerpt

BACKGROUND: MDM4, also called MDMX or HDMX in humans, is an important negative regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers and more frequently in some types, such as colon cancer or retinoblastoma. MDM4 is known to be post-translationally regulated by MDM2-mediated ubiquitination to decrease its protein levels in response to genotoxic stress, resulting in accumulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22870278
DOI: 10.1371/journal.pone.0042034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading FramePMID 22870278Read ↗

An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity.Semantic proximity Read ↗

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.Semantic proximity Read ↗

MDM4: What do we know about the association between its polymorphisms and cancer?Semantic proximity Read ↗

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.Semantic proximity Read ↗

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesisSemantic proximity Read ↗

MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.Semantic proximity Read ↗

The long and the short of it: the MDM4 tail so farSemantic proximity Read ↗

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

microRNA-34a promotes DNA damage and mitotic catastrophe.Semantic proximity Read ↗

The p53 mRNA-Mdm2 interaction.Semantic proximity Read ↗

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.Semantic proximity Read ↗

The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.