A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.

doi:10.1530/ERC-15-0013

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Article

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.

Endocrine-related cancer - 1 Apr 2015

Stegeman Shane, Moya Leire, Selth Luke A, Spurdle Amanda B, Clements Judith A, Batra Jyotsna

Abstract excerpt

The oncogene MDM4, also known as MDMX or HDMX, contributes to cancer susceptibility and progression through its capacity to negatively regulate a range of genes with tumour-suppressive functions. As part of a recent genome-wide association study it was determined that the A-allele of the rs4245739 SNP (A>C), located in the 3'-UTR of MDM4, is associated with an increased risk of prostate cancer. Computational...

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PMID: 25670033
DOI: 10.1530/ERC-15-0013

Genes

MDM4

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