Article
MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.
PloS one - 24 Dec 2009
Mishra Prasun J, Song Bo, Mishra Pravin J, Wang Yuan, Humeniuk Rita, Banerjee Debabrata, Merlino Glenn, Ju Jingfang, Bertino Joseph R
Abstract excerpt
MicroRNAs (miRNAs) are predicted to regulate approximately 30% of all human genes; however, only a few miRNAs have been assigned their targets and specific functions. Here we demonstrate that miR-24, a ubiquitously expressed miRNA, has an anti-proliferative effect independent of p53 function. Cel...
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