The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.

doi:10.1007/s13277-016-4940-2

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Article

The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016

Gansmo Liv B, Bjørnslett Merete, Halle Mari Kyllesø, Salvesen Helga B, Dørum Anne, Birkeland Einar, Hveem Kristian, Romundstad Pål, Vatten Lars, Lønning Per Eystein, Knappskog Stian

Abstract excerpt

The MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single nucleotide polymorphism (SNP) in the 3' untranslated region of the MDM4 gene, SNP34091A > C (rs4245739) was reported to alter MDM4 messenger RNA (mRNA)...

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PMID: 26867771
DOI: 10.1007/s13277-016-4940-2
PMCID: PMC4999457

Genes

MDM4
MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.PMID 26867771Read ↗

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MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

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