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Article

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.

PloS one - 1 Jan 2012

McEvoy Justina, Ulyanov Anatoly, Brennan Rachel, Wu Gang, Pounds Stanley, Zhang Jinghui, Dyer Michael A

Abstract excerpt

Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma. The p53 gene is intact in human retinoblastoma but the pathway is believed to be supp...

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Source

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Identifiers

PMID: 22916154
DOI: 10.1371/journal.pone.0042739
PMCID: PMC3423419

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22916154-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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