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Article

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.

PloS one - 1 Jan 2012

McEvoy Justina, Ulyanov Anatoly, Brennan Rachel, Wu Gang, Pounds Stanley, Zhang Jinghui, Dyer Michael A

Abstract excerpt

Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma. The p53 gene is intact in human retinoblastoma but the pathway is believed to be suppressed by increased expression of MDM4 (MDMX) and MDM2. Here we quantify the expression of MDM4 and MDM2 mRNA and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22916154
DOI: 10.1371/journal.pone.0042739
PMCID: PMC3423419

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.PMID 22916154Read ↗

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