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The long and the short of it: the MDM4 tail so far

21 Jan 2019

Abstract excerpt

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilitates MDM2's E3 ligase activity toward p53. These functions of MDM4 are critical for normal cell...

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PMID: 30689920
DOI: 10.1093/jmcb/mjz007

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