Article
An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity.
Cancer research - 1 Dec 2010
Wynendaele Jessika, Böhnke Anja, Leucci Eleonora, Nielsen Søren Jensby, Lambertz Irina, Hammer Stefanie, Sbrzesny Nadja, Kubitza Dana, Wolf Anja, Gradhand Elise, Balschun Katharina, Braicu Ioana, Sehouli Jalid, Darb-Esfahani Silvia, Denkert Carsten, Thomssen Christoph, Hauptmann Steffen, Lund Anders, Marine Jean-Christophe, Bartel Frank
Abstract excerpt
Overexpression of MDM4 (also known as MDMX or HDMX) is thought to promote tumorigenesis by decreasing p53 tumor suppressor function. Even modest decrease in Mdm4 levels affects tumorigenesis in mice, suggesting that genetic variants of MDM4 might have similar effects in humans. We sequenced the MDM4 gene in a series of ovarian cancer cell lines and carcinomas to identify mutations and/or single nucleotide...
Topics
- 3' Untranslated Regions
- Aged
- Binding Sites
- Blotting, Western
- Cell Cycle Proteins
- Cell Line, Tumor
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic