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MDM4: What do we know about the association between its polymorphisms and cancer?

Medical oncology (Northwood, London, England) - 24 Dec 2022

Almeida Gabriela Mattevi, Castilho Ana Clara, Adamoski Douglas, Braun-Prado Karin

Abstract excerpt

MDM4 is an important p53-negative regulator, consequently, it is involved in cell proliferation, DNA repair, and apoptosis regulation. MDM4 overexpression and amplification are described to lead to cancer formation, metastasis, and poor disease prognosis. Several MDM4 SNPs are in non-coding regions, and some affect the MDM4 regulation by disrupting the micro RNA binding site in 3'UTR (untranslated region). Here,...

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PMID: 36566308
DOI: 10.1007/s12032-022-01929-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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