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Article

Regulation of hepatic insulin sensitivity by activating signal co-integrator-2.

The Biochemical journal - 1 Nov 2012

Kim Geun Hyang, Lee Kyung Jin, Oh Gyun-Sik, Yoon Jin, Kim Hae Won, Kim Seung-Whan

Abstract excerpt

ASC-2 (activating signal co-integrator-2, also known as AIB3 and NCoA6) is a transcriptional co-activator and regulates insulin secretion and β-cell survival. The present study was performed to elucidate the role of ASC-2 in the regulation of insulin sensitivity. Although islet cells from 10-week-old ASC-2+/- mice secreted less insulin than wild-type islets, there was no significant difference in glucose...

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Source

Identifiers

PMID: 22861055
DOI: 10.1042/BJ20120861

Genes

SOCS1
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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