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Article

The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.

Diabetologia - 1 Sept 2010

Lebrun P, Cognard E, Gontard P, Bellon-Paul R, Filloux C, Berthault M F, Magnan C, Ruberte J, Luppo M, Pujol A, Pachera N, Herchuelz A, Bosch F, Van Obberghen E

Abstract excerpt

AIMS/HYPOTHESIS: Suppressor of cytokine signalling (SOCS) proteins are powerful inhibitors of pathways involved in survival and function of pancreatic beta cells. Whereas SOCS1 and SOCS3 have been involved in immune and inflammatory processes, respectively, in beta cells, nothing is known about SOCS2 implication in the pancreas. METHODS: Transgenic (tg) mice were generated that constitutively produced SOCS2 in...

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Identifiers

PMID: 20499047
DOI: 10.1007/s00125-010-1786-9

Genes

SOCS2
SOCS1
SOCS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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