Article
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
Cell - 4 May 2007
Wellen Kathryn E, Fucho Raquel, Gregor Margaret F, Furuhashi Masato, Morgan Carlos, Lindstad Torstein, Vaillancourt Eric, Gorgun Cem Z, Saatcioglu Fahri, Hotamisligil Gökhan S
Abstract excerpt
Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of chronic stress. Thus, we hypothesized that mechanisms might exist to prevent overt inflammatory responses during physiological fluctuations in nutrients or under nutrient-rich conditions, and we identified the...
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