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Article

Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005

Rico-Bautista Elizabeth, Greenhalgh Christopher J, Tollet-Egnell Petra, Hilton Douglas J, Alexander Warren S, Norstedt Gunnar, Flores-Morales Amilcar

Abstract excerpt

Suppressor of cytokine signaling-2 (SOCS2)-deficient (SOCS2-/-) mice grow significantly larger than their littermates, suggesting that SOCS2 is important in the negative regulation of the actions of GH and/or IGF-I. The aim of this study was to identify genes and metabolic parameters that might contribute to the SOCS2-/- phenotype. We demonstrate that although SOCS2 deficiency induces significant changes in...

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Identifiers

PMID: 15563548
DOI: 10.1210/me.2004-0040

Genes

SOCS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.PMID 15563548Read ↗

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