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Article

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.

Diabetes - 1 Mar 2006

Shi Hang, Cave Belinda, Inouye Karen, Bjørbaek Christian, Flier Jeffrey S

Abstract excerpt

In adipocytes, suppressor of cytokine signaling (SOCS)3 deficiency increases insulin-stimulated insulin receptor substrate (IRS)-1 and -2 phosphorylation, IRS-associated phosphatidylinositol 3 kinase activity, and insulin-stimulated glucose uptake. Moreover, SOCS3 is required for tumor necrosis f...

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Source

Identifiers

PMID: 16505233
DOI: 10.2337/diabetes.55.03.06.db05-0841

Genes

SOCS3
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-16505233-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.PMID 16505233Read ↗

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.Semantic proximity Read ↗

Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytesSemantic proximity Read ↗

SOCS-3 is an insulin-induced negative regulator of insulin signaling.Semantic proximity Read ↗

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.Semantic proximity Read ↗

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.Semantic proximity Read ↗

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in ObesitySemantic proximity Read ↗

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.Semantic proximity Read ↗

Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseasesSemantic proximity Read ↗

SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changesSemantic proximity Read ↗

STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta.Semantic proximity Read ↗

Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.Semantic proximity Read ↗

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